#Primordia rag full

Diverse organization of immunoglobulin VH gene loci in a primitive vertebrate. Kokubu F, Litman R, Shamblott MJ, Hinds K, Litman GW.Antigenic cross-reactions among immunoglobulin of diverse vertebrates (elasmobranchs to man) detected using xenoantisera. Marchalonis JJ, Schluter SF, Yang HY, Hohman VS, McGee K, Yeaton L.Complete nucleotide sequence of primitive vertebrate immunoglobulin light chain genes. Immunoglobulin light chain class multiplicity and alternative organizational forms in early vertebrate phylogeny. Rast JP, Anderson MK, Ota T, Litman RT, Margittai M, Shamblott MJ, Litman GW.Genomic clone for sandbar shark lambda light chain: generation of diversity in the absence of gene rearrangement. Hohman VS, Schuchman DB, Schluter SF, Marchalonis JJ.On the relevance of invertebrate recognition and defence mechanisms to the emergence of the immune response of vertebrates. Are invertebrates capable of anticipatory immune responses? Scand J Immunol. Links to PubMed are also available for Selected References. Get a printable copy (PDF file) of the complete article (2.1M), or click on a page image below to browse page by page.

#Primordia rag full

Full textįull text is available as a scanned copy of the original print version. Thus, the apparent explosive evolution (or 'big bang') of the ancestral immune system may have been initiated by a transfer of microbial site-specific recombinases. Homology domains identified within shark RAG I prompted sequence comparison analyses that suggested similarity of the RAG I and II genes, respectively, to the integrase family genes and integration host factor genes of the bacterial site-specific recombination system. To elucidate their origin and function, the cDNA encoding RAG I from a member of the most ancient class of extant gnathostomes, the Carcharhine sharks, was characterized. This ability is conferred by the recombination activating genes I and II (RAG I and RAG II). All extant jawed vertebrates can rearrange these gene segments. The rearrangement of antibody and T-cell receptor gene segments is indispensable to the vertebrate immune response.